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Article

Mutations in the 1.1 subdomain of Escherichia coli sigma factor sigma70 and disruption of its overall structure.

European journal of biochemistry - 1 Mar 1997

Gopal V, Chatterji D

Abstract excerpt

Among various group I sigma factors, two amino acids, Val55 and Ala59 are the conserved amino acids in the 1.1 hydrophobic subdomain. These two sites have been mutated to generate variants designated as [Gly55]sigma70 and [Gly59]sigma70, where glycine replaces valine and alanine, respectively. Th...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Binding Sites
Conserved Sequence
DNA Primers
DNA-Binding Proteins
DNA-Directed RNA Polymerases
Escherichia coli
Genetic Variation
Molecular Structure
Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Sequence Homology, Amino Acid

Sigma Factor

Source

Identifiers

PMID: 9119031
DOI: 10.1111/j.1432-1033.1997.00613.x

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9119031-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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