Article
Interacting quantitative trait loci control phenotypic variation in murine estradiol-regulated responses.
Endocrinology - 1 Feb 1999
Roper R J, Griffith J S, Lyttle C R, Doerge R W, McNabb A W, Broadbent R E, Teuscher C
Abstract excerpt
The steroid hormone estradiol (E2) elicits a spectrum of systemic and uterotropic responses in vivo. For example, E2 treatment of ovariectomized adult and sexually immature rodents leads to uterine leukocytic infiltration, cell proliferation, and organ growth. E2-regulated growth is also associated with a variety of normal and pathological phenotypes. Historically, the uterine growth response has been used as the...
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