Article
Regulatory variation at glypican-3 underlies a major growth QTL in mice.
PLoS biology - 1 May 2005
Oliver Fiona, Christians Julian K, Liu Xiaojun, Rhind Susan, Verma Vinesh, Davison Claire, Brown Steve D M, Denny Paul, Keightley Peter D
Abstract excerpt
The genetic basis of variation in complex traits remains poorly understood, and few genes underlying variation have been identified. Previous work identified a quantitative trait locus (QTL) responsible for much of the response to selection on growth in mice, effecting a change in body mass of approximately 20%. By fine-mapping, we have resolved the location of this QTL to a 660-kb region containing only two...
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