Article
Transcription factor effects on chromosome constitution of cell hybrids.
Cytogenetics and cell genetics - 1 Jan 1998
Hines M D, Radomska H S, Eckhardt L A
Abstract excerpt
When immunoglobulin (Ig)-secreting plasmacytomas are fused to a T-cell lymphoma, Ig gene expression ceases in greater than 95% of the resulting hybrids. In the rare hybrids that continue to express Ig, all other tested B lymphocyte-specific genes also remain active. The low frequency with which t...
Topics
- Animals
- Chromosome Mapping
- Chromosomes
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Humans
- Hybrid Cells
- Immunoglobulins
- Lymphoma, T-Cell
- Mice
- Mice, Inbred AKR
- Mice, Inbred BALB C
- Octamer Transcription Factor-2
- Oligonucleotide Probes
- Phenotype
- Plasma Cells
- Plasmacytoma