Article
Chromosomal influence on hybrid cell proliferation.
Cell proliferation - 1 Jul 1992
McGill J R, Lalley P J, Leach R J, Johnson T J, Von Hoff D D
Abstract excerpt
When normal cells and cancer cells (usually from the same species) are experimentally fused the resultant hybrid cells show loss of the tumorigenic phenotype. To examine the phenotypic phenomenon of growth suppression in hybrid cells in vitro, we examined the doubling times of somatic cell hybrids which contained single or multiple chromosomes derived from another species (inter-species hybrids). In all of the...
Topics
- Animals
- Cell Cycle
- Cell Division
- Chromosomes
- Cricetinae
- Humans
- Hybrid Cells
- Interphase
- Metaphase
- Mice
- Phenotype