Article
Increased expression of a hemimethylated oriC binding protein, SeqA, in an aphA mutant.
Biochimie - 1 Dec 1998
Kohiyama M, Bahloul A, Kern R, Meury J, Reshetnyak E, Malki A, Guha S
Abstract excerpt
In Escherichia coli, the origin of DNA replication, oriC, becomes transiently hemimethylated at the GATC sequences immediately after initiation of replication and this hemimethylated state is prolonged because of its sequestration by a fraction of outer membrane. This sequestration is dependent on a hemimethylated oriC binding protein such as SeqA. We previously isolated a clone of phage lambda gt11 called hobH,...
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