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Article

Parental strand recognition of the DNA replication origin by the outer membrane in Escherichia coli.

The EMBO journal - 3 Oct 1994

Herrick J, Kern R, Guha S, Landoulsi A, Fayet O, Malki A, Kohiyama M

Abstract excerpt

The outer membrane of Escherichia coli binds the origin of DNA replication (oriC) only when it is hemimethylated. We report here the results of a footprinting analysis with the outer membrane which demonstrate that its interaction with oriC occurs mainly at the left moiety of the minimal oriC, where 10 out of 11 Dam methylation sites are concentrated. Two regions, flanking the Integration Host Factor (IHF) sites,...

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Identifiers

PMID: 7925311
DOI: 10.1002/j.1460-2075.1994.tb06793.x
PMCID: PMC395404

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