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Article

Streptococcal preparation OK432 promotes functional maturation of human monocyte-derived dendritic cells.

Cancer immunology, immunotherapy : CII - 1 Apr 2003

Itoh Tsuyoshi, Ueda Yuji, Okugawa Kaori, Fujiwara Hitoshi, Fuji Nobuaki, Yamashita Tetsuro, Fujiki Hiroshi, Harada Sachio, Yoshimura Tetsunori, Yamagishi Hisakazu

Abstract excerpt

Streptococcal preparation OK432 is an immunomodulatory agent extensively used as adjuvant therapy for gastric cancer in Japan. OK432 augments the cytotoxic activity of various effector cells such as lymphocytes, macrophages and (natural killer) NK cells and induces the production of multiple cytokines. Dendritic cells (DC) are professional antigen-presenting cells (APC) that can be used for cancer vaccine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12669245
DOI: 10.1007/s00262-002-0337-8
PMCID: PMC11032845

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APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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