Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.

Environmental health perspectives - 1 Feb 2010

Feige Jérôme N, Gerber Alan, Casals-Casas Cristina, Yang Qian, Winkler Carine, Bedu Elodie, Bueno Manuel, Gelman Laurent, Auwerx Johan, Gonzalez Frank J, Desvergne Béatrice

Abstract excerpt

BACKGROUND: The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Energy Metabolism
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Mice, Transgenic

Share to Obesity

Share to Oxidation-Reduction

Share to PPAR alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 20123618
DOI: 10.1289/ehp.0901217
PMCID: PMC2831923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20123618-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.PMID 20123618Read ↗

Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice.Semantic proximity Read ↗

Perinatal exposure to 2-Ethylhexyl Diphenyl Phosphate (EHDPHP) affected the metabolic homeostasis of male mouse offspring: Unexpected findings help to explain dose- and diet- specific phenomena.Semantic proximity Read ↗

Di-(2-ethylhexyl) phthalate accelerates atherosclerosis in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health ThreatSemantic proximity Read ↗

Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.Semantic proximity Read ↗

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and HumanSemantic proximity Read ↗

Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differencesSemantic proximity Read ↗

Glucoregulatory Reprogramming in Male Mice Offspring Induced by Maternal Transfer of Indoor Flame Retardant Endocrine DisruptorsSemantic proximity Read ↗

Hepatocarcinogenic Potential of Di(2-Ethylhexyl)phthalate in Rodents and its Implications on Human RiskSemantic proximity Read ↗

Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47)Semantic proximity Read ↗

Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.Semantic proximity Read ↗

Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.