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Article

Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow.

Transplantation - 15 Aug 2005

Zhang Jia Lin, Cai Jin, Walls Shannon, Jackson John D, Kuszynski Charles A, Zhao Yong, Pawliuk Robert, Leboulch Philippe, Fox Ira J

Abstract excerpt

BACKGROUND: Application of gene therapy to induce antigen-specific immune tolerance could be important for transplantation or treatment of autoimmune diseases. Hematopoietic stem cell-based gene therapy has been hampered by relatively weak gene expression in vivo and loss of transduced cells over time. Selective expansion of transduced hematopoietic stem cells has been accomplished by incorporating the...

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PMID: 16082332
DOI: 10.1097/01.tp.0000165791.39723.a1

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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