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Article

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation.

Blood - 15 Sept 2006

Amrolia Persis J, Muccioli-Casadei Giada, Huls Helen, Adams Stuart, Durett April, Gee Adrian, Yvon Eric, Weiss Heidi, Cobbold Mark, Gaspar H Bobby, Rooney Cliona, Kuehnle Ingrid, Ghetie Victor, Schindler John, Krance Robert, Heslop Helen E, Veys Paul, Vitetta Ellen, Brenner Malcolm K

Abstract excerpt

Poor T lymphocyte reconstitution limits the use of haploidentical stem cell transplantation (SCT) because it results in a high mortality from viral infections. One approach to overcome this problem is to infuse donor T cells from which alloreactive lymphocytes have been selectively depleted, but the immunologic benefit of this approach is unknown. We have used an anti-CD25 immunotoxin to deplete alloreactive...

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Source

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Identifiers

PMID: 16741253
DOI: 10.1182/blood-2006-02-001909
PMCID: PMC1895537

Genes

SCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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