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Article

Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population.

Haematologica - 1 Jul 2009

Blanco Belén, Pérez-Simón José A, Sánchez-Abarca Luis I, Caballero-Velazquez Teresa, Gutierrez-Cossío Silvia, Hernández-Campo Pilar, Díez-Campelo María, Herrero-Sanchez Carmen, Rodriguez-Serrano Concepción, Santamaría Carlos, Sánchez-Guijo Fermín M, Del Cañizo Consuelo, San Miguel Jesús F

Abstract excerpt

BACKGROUND: In vitro depletion of alloreactive T cells using the proteasome inhibitor bortezomib is a promising approach to prevent graft-versus-host disease after allogeneic stem cell transplantation. We have previously described the ability of bortezomib to selectively eliminate alloreactive T...

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Identifiers

PMID: 19508976
DOI: 10.3324/haematol.2008.005017
PMCID: PMC2704308

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19508976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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