Article
Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rgamma(null) mice.
Experimental hematology - 1 Apr 2008
Distler Eva, Wölfel Catherine, Köhler Sylvia, Nonn Marion, Kaus Nina, Schnürer Elke, Meyer Ralf G, Wehler Thomas C, Huber Christoph, Wölfel Thomas, Hartwig Udo F, Herr Wolfgang
Abstract excerpt
OBJECTIVE: Current in vitro techniques for isolating leukemia-reactive cytotoxic T lymphocytes (CTLs) from healthy donors are of relatively low efficiency and yield responder populations with unknown biological significance. This study aimed at the development of a more reliable approach, allowing generation and expansion of acute myeloid leukemia (AML)-reactive CTLs using primary in vitro stimulation. MATERIALS...
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