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Article

UV-induced mutations and skin cancer: how important is the link?

Mutation research - 9 Nov 1998

Bridges B A

Abstract excerpt

Studies with patients having the inherited DNA repair disorders xeroderma pigmentosum (XP), Cockayne syndrome (CS), and sun-sensitive trichothiodystrophy (TTD) have shown that neither the defect in repair nor the consequent elevated frequency of sunlight-induced mutations in the skin is sufficient to account for the classically high incidence of skin cancer in XP patients. The possible ways in which different...

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Identifiers

PMID: 9920425
DOI: 10.1016/s0027-5107(98)00172-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

UV-induced mutations and skin cancer: how important is the link?PMID 9920425Read ↗

Xeroderma pigmentosum and skin cancer.Semantic proximity Read ↗

Absence of skin cancer in the DNA repair-deficient disease Cockayne Syndrome (CS): A survey studySemantic proximity Read ↗

Sunlight-induced cancer: some new aspects and implications of the xeroderma pigmentosum model.Semantic proximity Read ↗

Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.Semantic proximity Read ↗

Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes.Semantic proximity Read ↗

Abnormal erythemal response and elevated T lymphocyte HRPT mutant frequency in Cockayne's syndrome.Semantic proximity Read ↗

The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.Semantic proximity Read ↗

UV-induced mutations in a shuttle vector replicated in repair deficient trichothiodystrophy cells differ with those in genetically-related cancer prone xeroderma pigmentosum.Semantic proximity Read ↗

Immune function, mutant frequency, and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy.Semantic proximity Read ↗

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