Article
Xeroderma pigmentosum and skin cancer.
Advances in experimental medicine and biology - 1 Jan 2008
Daya-Grosjean Leela
Abstract excerpt
The hypersensitivity of DNA repair deficient xeroderma pigmentosum (XP) patients to solar irradiation results in the development of high levels of squamous and basal cell carcinomas as well as malignant melanomas in early childhood. Indeed, XP presents a unique model for analysing the effects of unrepaired DNA lesions in skin carcinogenesis. The skin cancer predisposition, observed in XP patients, is due to the...
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