The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.

doi:10.1016/s0167-4889(98)00135-9

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Article

The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.

Biochimica et biophysica acta - 10 Dec 1998

Zhu G, Davis T N

Abstract excerpt

We previously identified HCM1 as a dosage-dependent suppressor of a calmodulin temperature-sensitive mutant (cmd1-1). Calmodulin performs multiple functions in yeast. Here we demonstrate that the effects of HCM1 are specific to the role of calmodulin at the spindle pole body. Overexpression of HC...

Topics

Amino Acid Sequence
Calmodulin
Calmodulin-Binding Proteins
Consensus Sequence
Cytoskeletal Proteins
DNA
DNA-Binding Proteins
Forkhead Transcription Factors
Fungal Proteins
Gene Expression Regulation
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Promoter Regions, Genetic

Saccharomyces cerevisiae Proteins

Sequence Alignment

Spindle Apparatus

Temperature

Source

Open in PubMed

Identifiers

PMID: 9920414
DOI: 10.1016/s0167-4889(98)00135-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9920414-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.PMID 9920414Read ↗

Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation.Semantic proximity Read ↗

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Genetic Analysis of Calmodulin and Its Targets in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects.Semantic proximity Read ↗

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Fine structure analysis of the yeast centrin, Cdc31p, identifies residues specific for cell morphology and spindle pole body duplication.Semantic proximity Read ↗

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