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Article

Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body.

The EMBO journal - 15 Sept 1994

Stirling D A, Welch K A, Stark M J

Abstract excerpt

NUF1/SPC110, encoding a nuclear filament-related protein which is a component of the yeast spindle pole body (SPB), has been identified in a screen designed to isolate genes encoding targets of yeast calmodulin. Spc110p interacts with calmodulin by two different criteria and the calmodulin interacting region has been localized within the C-terminus of the protein. Point mutations between residues 898 and 917...

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Identifiers

PMID: 7925277
DOI: 10.1002/j.1460-2075.1994.tb06753.x
PMCID: PMC395360

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Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body.PMID 7925277Read ↗

Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation.Semantic proximity Read ↗

Role of calmodulin and Spc110p interaction in the proper assembly of spindle pole body compenents.Semantic proximity Read ↗

Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects.Semantic proximity Read ↗

The 110-kD spindle pole body component of Saccharomyces cerevisiae is a phosphoprotein that is modified in a cell cycle-dependent manner.Semantic proximity Read ↗

A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Calmodulin localizes to the spindle pole body of Schizosaccharomyces pombe and performs an essential function in chromosome segregation.Semantic proximity Read ↗

Spc110p: assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body.Semantic proximity Read ↗

Genetic Analysis of Calmodulin and Its Targets in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.Semantic proximity Read ↗

Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity.Semantic proximity Read ↗

A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex.Semantic proximity Read ↗

Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces.Semantic proximity Read ↗

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