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Article

Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity.

The Journal of cell biology - 1 Dec 1992

Sun G H, Hirata A, Ohya Y, Anraku Y

Abstract excerpt

Yeast calmodulin (CaM) is required for the progression of nuclear division (Ohya, Y. and Y. Anraku. 1989. Curr. Genet. 15:113-120), although the precise mechanism and physiological role of CaM in this process are unclear. In this paper we have characterized the phenotype caused by a temperature-sensitive lethal mutation (cmdl-101) in the yeast CaM. The cmdl-101 mutation expresses a carboxyl-terminal half of the...

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Identifiers

PMID: 1469052
DOI: 10.1083/jcb.119.6.1625
PMCID: PMC2289758

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Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity.PMID 1469052Read ↗

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Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation.Semantic proximity Read ↗

Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body.Semantic proximity Read ↗

Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects.Semantic proximity Read ↗

Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces.Semantic proximity Read ↗

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The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.Semantic proximity Read ↗

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