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Article

Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects.

Journal of cell science - 1 Jun 1996

Stirling D A, Rayner T F, Prescott A R, Stark M J

Abstract excerpt

We have generated three temperature-sensitive alleles of SPC110, which encodes the 110 kDa component of the yeast spindle pole body (SPB). Each of these alleles carries point mutations within the calmodulin (CaM) binding site of Spc110p which affect CaM binding in vitro; two of the mutant proteins fail to bind CaM detectably (spc110-111, spc110-118) while binding to the third (spc110-124) is...

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Identifiers

PMID: 8799819
DOI: 10.1242/jcs.109.6.1297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations which block the binding of calmodulin to Spc110p cause multiple mitotic defects.PMID 8799819Read ↗

Mutations in SPC110, encoding the yeast spindle pole body calmodulin-binding protein, cause defects in cell integrity as well as spindle formation.Semantic proximity Read ↗

Role of calmodulin and Spc110p interaction in the proper assembly of spindle pole body compenents.Semantic proximity Read ↗

Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body.Semantic proximity Read ↗

Spc110p: assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body.Semantic proximity Read ↗

The 110-kD spindle pole body component of Saccharomyces cerevisiae is a phosphoprotein that is modified in a cell cycle-dependent manner.Semantic proximity Read ↗

A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces.Semantic proximity Read ↗

A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex.Semantic proximity Read ↗

Calmodulin localizes to the spindle pole body of Schizosaccharomyces pombe and performs an essential function in chromosome segregation.Semantic proximity Read ↗

A temperature-sensitive calmodulin mutant loses viability during mitosis.Semantic proximity Read ↗

Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity.Semantic proximity Read ↗

The fork head transcription factor Hcm1p participates in the regulation of SPC110, which encodes the calmodulin-binding protein in the yeast spindle pole body.Semantic proximity Read ↗

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