Article
DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease.
The Journal of clinical endocrinology and metabolism - 1 Jan 1999
Yu L, Brewer K W, Gates S, Wu A, Wang T, Babu S R, Gottlieb P A, Freed B M, Noble J, Erlich H A, Rewers M J, Eisenbarth G S
Abstract excerpt
Of 957 patients with type 1 diabetes without known Addison's disease 1.6% (n = 15) were positive for 21-hydroxylase autoantibodies. Among DQ8/DQ2 heterozygous patients, the percentage expressing 21-hydroxylase autoantibodies was 5% (10 of 208) vs. less than 0.5% of patients with neither DQ8 nor D...
Topics
- Addison Disease
- Adolescent
- Adult
- Alleles
- Autoantibodies
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Infant
- Middle Aged
- Risk