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Article

DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease.

The Journal of clinical endocrinology and metabolism - 1 Jan 1999

Yu L, Brewer K W, Gates S, Wu A, Wang T, Babu S R, Gottlieb P A, Freed B M, Noble J, Erlich H A, Rewers M J, Eisenbarth G S

Abstract excerpt

Of 957 patients with type 1 diabetes without known Addison's disease 1.6% (n = 15) were positive for 21-hydroxylase autoantibodies. Among DQ8/DQ2 heterozygous patients, the percentage expressing 21-hydroxylase autoantibodies was 5% (10 of 208) vs. less than 0.5% of patients with neither DQ8 nor DQ2. Three of the diabetic patients found to have 21-hydroxylase autoantibodies on screening were subsequently diagnosed...

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Identifiers

PMID: 9920103
DOI: 10.1210/jcem.84.1.5414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease.PMID 9920103Read ↗

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