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Article

Dominant suppression of Addison's disease associated with HLA-B15.

The Journal of clinical endocrinology and metabolism - 1 Jul 2011

Baker Peter R, Baschal Erin E, Fain Pam R, Nanduri Priyaanka, Triolo Taylor M, Siebert Janet C, Armstrong Taylor K, Babu Sunanda R, Rewers Marian J, Gottlieb Peter A, Barker Jennifer M, Eisenbarth George S

Abstract excerpt

CONTEXT: Autoimmune Addison's disease (AD) is the major cause of primary adrenal failure in developed nations. Autoantibodies to 21-hydroxylase (21OH-AA) are associated with increased risk of progression to AD. Highest genetic risk is associated with the Major Histocompatibility region (MHC), specifically human leukocyte antigen (HLA)-DR3 haplotypes (containing HLA-B8) and HLA-DR4. OBJECTIVE: The objective of the...

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Share to Addison Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 21565792
DOI: 10.1210/jc.2010-2964
PMCID: PMC3135206

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Dominant suppression of Addison's disease associated with HLA-B15.PMID 21565792Read ↗

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