Article
Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Nov 2009
Triolo Taylor M, Baschal Erin E, Armstrong Taylor K, Toews Carrie S, Fain Pamela R, Rewers Marian J, Yu Liping, Miao Dongmei, Eisenbarth George S, Gottlieb Peter A, Barker Jennifer M
Abstract excerpt
CONTEXT: Autoimmunity associated with Addison's disease (AD) can be detected by measuring 21-hydroxylase (21OH) autoantibodies. Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and w...
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