Article
Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo.
Virology - 20 Jan 1999
Gorelick R J, Benveniste R E, Gagliardi T D, Wiltrout T A, Busch L K, Bosche W J, Coren L V, Lifson J D, Bradley P J, Henderson L E, Arthur L O
Abstract excerpt
All retroviruses (except the spumaretroviruses) contain a nucleocapsid (NC) protein that encodes one or two copies of the Zn2+-finger sequence -Cys-X2-Cys-X4-His-X4-Cys-. This region has been shown to be essential for recognition and packaging of the genomic RNA during virion particle assembly. A...
Topics
- Amino Acid Sequence
- Animals
- Cell Line, Transformed
- Cysteine
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Nucleocapsid Proteins
- Polymerase Chain Reaction