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Nucleocapsid protein zinc-finger mutants of simian immunodeficiency virus strain mne produce virions that are replication defective in vitro and in vivo.

Virology - 20 Jan 1999

Gorelick R J, Benveniste R E, Gagliardi T D, Wiltrout T A, Busch L K, Bosche W J, Coren L V, Lifson J D, Bradley P J, Henderson L E, Arthur L O

Abstract excerpt

All retroviruses (except the spumaretroviruses) contain a nucleocapsid (NC) protein that encodes one or two copies of the Zn2+-finger sequence -Cys-X2-Cys-X4-His-X4-Cys-. This region has been shown to be essential for recognition and packaging of the genomic RNA during virion particle assembly. Additionally, this region has been shown to be involved in early infection events in a wide spectrum of retroviruses,...

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PMID: 9918884
DOI: 10.1006/viro.1998.9513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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