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Article

The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent

1 Jul 1993

Abstract excerpt

The highly conserved zinc fingers in retroviral nucleocapsid (NC) proteins have the general structure Cys-(X)2-Cys-(X)4-His-(X)4-Cys. Human immunodeficiency virus type 1 (HIV-1) contains two Zn2+ fingers, and mutants were constructed in which the native sequence of each Zn2+ finger was maintained but their positions in the NC protein were changed. Mutants had either two first-finger sequences (pNC1/1), two...

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Identifiers

PMID: 8510214
DOI: 10.1128/jvi.67.7.4027-4036.1993

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