Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages.

doi:10.1006/viro.1998.9482

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Article

Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages.

Virology - 20 Jan 1999

Kootstra N A, Schuitemaker H

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) is considered to infect nondividing cells because nuclear localization signals (NLS) in matrix (MA, p17(Gag)) and Vpr allow active nuclear transport of the preintegration complex. Previous studies demonstrated that HIV-1 reverse transcription is success...

Topics

Bromodeoxyuridine
Cell Cycle
Cell Division
Cells, Cultured
DNA, Viral
Gene Products, gag
Gene Products, vpr
Genetic Variation
HIV Antigens
HIV-1
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Mutagenesis

Nuclear Localization Signals

Peptide Chain Elongation, Translational

Phenotype

S Phase

Source

Open in PubMed

Identifiers

PMID: 9918876
DOI: 10.1006/viro.1998.9482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9918876-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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