Article
The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Heinzinger N K, Bukrinsky M I, Haggerty S A, Ragland A M, Kewalramani V, Lee M A, Gendelman H E, Ratner L, Stevenson M, Emerman M
Abstract excerpt
The replication of human immunodeficiency virus type 1 (HIV-1) in nondividing host cells such as those of macrophage lineage is an important feature of AIDS pathogenesis. The pattern of HIV-1 replication is dictated, in part, by the nucleophilic property of the viral gag matrix (MA) protein, a component of the viral preintegration complex that facilitates nuclear localization of viral nucleic acids in the absence...
Topics
- Base Sequence
- Cell Division
- Cell Line
- Cell Nucleus
- Cloning, Molecular
- DNA, Viral
- Gene Products, vpr
- HIV-1
- Humans
- Molecular Sequence Data