Article
The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells.
Journal of virology - 1 May 1998
Nie Z, Bergeron D, Subbramanian R A, Yao X J, Checroune F, Rougeau N, Cohen E A
Abstract excerpt
Several viral determinants were shown to play a role in the ability of human immunodeficiency virus type 1 (HIV-1) to infect nondividing cells. In particular, Vpr and Gag matrix (MA) were recognized to be involved in the nuclear transport of the viral preintegration complex. The goal of the prese...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Binding Sites
- Biological Transport
- COS Cells
- Cell Division
- Cell Line, Transformed
- Cell Nucleus
- Cloning, Molecular
- DNA
- DNA, Viral
- Gene Products, vpr
- HIV-1