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Article

A new locus for autosomal recessive hypercholesterolemia maps to human chromosome 15q25-q26.

American journal of human genetics - 1 Feb 2000

Ciccarese M, Pacifico A, Tonolo G, Pintus P, Nikoshkov A, Zuliani G, Fellin R, Luthman H, Maioli M

Abstract excerpt

High serum cholesterol is an established risk factor for cardiovascular disease and is the prime target for therapeutic intervention in large groups of patients. The development of modern treatments for this major risk factor was propelled by the early realization that forms of severe hypercholesterolemia could be caused by dominantly inherited defects in the LDL receptor or in the APOB gene. Further...

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Source

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Identifiers

PMID: 10677305
DOI: 10.1086/302753
PMCID: PMC1288098

Genes

APOB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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