[Molecular patho-biochemistry and genetic diagnosis for plasminogen-apolipoprotein (a) gene family related to atherosclerosis and thrombosis].

Abstract excerpt

Plasminogen is a key proenzyme of plasmin in the fibrinolytic and thrombolytic systems, the deficiency of which leads to a mild thrombotic tendency. Plasminogen binds to fibrin as well as to the surface of endothelial cells and monocytes/macrophages, where it is activated to plasmin. Individuals with dysplasminogenemia were analyzed by a combination of PCR and restriction digestion. Among 125 unrelated families,...

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