A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus.

doi:10.1086/302189

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Article

A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus.

American journal of human genetics - 1 Jan 1999

Dolan C V, Boomsma D I, Neale M C

Abstract excerpt

Sib pair-selection strategies, designed to identify the most informative sib pairs in order to detect a quantitative-trait locus (QTL), give rise to a missing-data problem in genetic covariance-structure modeling of QTL effects. After selection, phenotypic data are available for all sibs, but mar...

Topics

Alleles
Gene Frequency
Genetic Markers
Humans
Models, Genetic
Nuclear Family
Quantitative Trait, Heritable
Software

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