Article
Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped.
Genetic epidemiology - 1 Jan 1997
Todorov A A, Siegmund K D, Gu C, Borecki I B, Elston R C
Abstract excerpt
An assumption-free algorithm has been applied to compute the probabilities of all possible identity-by-descent (IBD) configurations when the parents have not been genotyped. These probabilities can be used to determine the amount of information that a particular sibship will bring to a nonparametric linkage analysis. It is shown that the number of possible configurations can be extremely large even when the...
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