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Article

Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.

Science (New York, N.Y.) - 22 Jan 1999

Jiang Y, Woronicz J D, Liu W, Goeddel D V

Abstract excerpt

Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-kappaB) activation. Normally, these signals are generated only after TNF-induced receptor aggregation. However, TNF-R1 self-associates and signals independently of ligand when overexpressed. This apparent paradox may be explained...

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Identifiers

PMID: 9915703
DOI: 10.1126/science.283.5401.543

Genes

TNF
TRADD
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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