Article
Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.
Science (New York, N.Y.) - 22 Jan 1999
Jiang Y, Woronicz J D, Liu W, Goeddel D V
Abstract excerpt
Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-kappaB) activation. Normally, these signals are generated only after TNF-induced receptor aggregation. However,...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Antigens, CD
- Apoptosis
- Carrier Proteins
- Cell Line
- Fas-Associated Death Domain Protein
- Humans
- Jurkat Cells
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Protein Binding
- Proteins
- Receptor Aggregation
- Receptor-Interacting Protein Serine-Threonine Kinases
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Member 25