Article
Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains.
Molecular and cellular biology - 1 Sept 2003
Endres Robert, Häcker Georg, Brosch Inge, Pfeffer Klaus
Abstract excerpt
The silencer of death domains (SODD) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 (TNFR1) in the absence of ligand. Besides TNFR1, death receptor 3 (DR3), Hsp70/Hsc70, and Bcl-2 have been characterized as binding partners of SODD. In order to investigate the in vivo role of SODD, we generated mice congenitally deficient in expression of the sodd gene. No spontaneous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.