Article
Critical residues of alphaX I-domain recognizing fibrinogen central domain.
Biochemical and biophysical research communications - 20 Apr 2007
Lee Joo Hee, Choi Jeongsuk, Nham Sang-Uk
Abstract excerpt
Integrin alphaXbeta2 (CD11c/CD18), which binds several ligands such as fibrinogen and iC3b, has important roles in leukocyte functions including phagocytosis and migration. Establishment of structure and functional relationship in alphaX I-domain, which is a ligand-binding moiety, is important in understanding leukocyte biology and integrin function. Previously we showed that two loops (alpha3-alpha4,...
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