Article
Current perspectives on BRCA1- and BRCA2-associated breast cancers.
Internal medicine journal - 1 Aug 2001
Phillips K A
Abstract excerpt
The identification of two breast cancer predisposition genes, BRCA1 and BRCA2, in the mid-1990s has led to a better understanding of the molecular pathogenesis of hereditary breast cancer and to a new era in breast cancer research. The present article reviews the current state of knowledge regarding the biology of BRCA1 and BRCA2, the cancer risks associated with carrying a pathogenic mutation in either of these...
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