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Article

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

19 Jan 1999

Abstract excerpt

In human cells, efficient global genomic repair of DNA damage induced by ultraviolet radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 gene is required for expression of an ultraviolet radiation-damaged DNA binding activity and is disrupted by mutations in the subset of xeroderma pigmentosum group E cells that lack this activity. Here, we show that p48 mRNA levels strongly...

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PMID: 9892649
DOI: 10.1073/pnas.96.2.424

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Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairPMID 9892649Read ↗

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Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53.Semantic proximity Read ↗

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