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Article

Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.

The Journal of biological chemistry - 14 Jul 2000

Nichols A F, Itoh T, Graham J A, Liu W, Yamaizumi M, Linn S

Abstract excerpt

Damage-specific DNA binding (DDB) activity purifies from HeLa cells as a heterodimer (p127 and p48) and is absent from cells of a subset (Ddb(-)) of xeroderma pigmentosum Group E (XPE) patients. Each subunit was overexpressed in insect cells and purified. Both must be present for the damaged DNA band shift characteristic of the HeLa heterodimer. However, overexpressed p48 peptides containing the mutations found...

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Source

Identifiers

PMID: 10777490
DOI: 10.1074/jbc.M000960200

Genes

DDB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.PMID 10777490Read ↗

Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype.Semantic proximity Read ↗

DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision RepairSemantic proximity Read ↗

Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains.Semantic proximity Read ↗

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.Semantic proximity Read ↗

Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.Semantic proximity Read ↗

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repairSemantic proximity Read ↗

p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.Semantic proximity Read ↗

Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53.Semantic proximity Read ↗

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