Article
Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding proteindependent cell-mediated cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Ma Y, Uemura K, Oka S, Kozutsumi Y, Kawasaki N, Kawasaki T
Abstract excerpt
Mannan-binding protein (MBP), a Ca2+-dependent mammalian lectin specific for mannose and N-acetylglucosamine, is an important serum component associated with innate immunity. MBP activates complement and functions as a direct opsonin on binding to mannooligosaccharide-bearing pathogens. We have found that MBP recognizes and binds specifically to oligosaccharide ligands expressed on the surfaces of a human...
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