Article
Targeted macrophage cytotoxicity using a nonreplicative live vector expressing a tumor-specific single-chain variable region fragment.
Human gene therapy - 1 Jul 2000
Paul S, Snary D, Hoebeke J, Allen D, Balloul J M, Bizouarne N, Dott K, Geist M, Hilgers J, Kieny M P, Burchell J, Taylor-Papadimitriou J, Acres R B
Abstract excerpt
Antigen-specific recognition and subsequent destruction of tumor cells is the goal of vaccine-based immunotherapy of cancer. Often, however, tumor antigen-specific cytotoxic T lymphocytes (CTLs) are either not available or in a state of anergy. In addition, MHCI expression on tumor cells is often downregulated. Either or both of these situations can allow tumor growth to proceed unchecked by CTL control. We have...
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