Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat.

doi:10.2337/diabetes.48.1.43

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Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat.

Diabetes - 1 Jan 1999

Lee E S, Jiang J, Sund G C, Simonson W T, Graham J, Dietsch G, Schimpf B, Bieg S, Peterman G, Lernmark A

Abstract excerpt

Platelet-activating factor (PAF) has been implicated in the development of type 1 diabetes. Our previous studies have suggested that PAF inhibitors reduce insulitis and the frequency of diabetes in BB rats. In this study, serum PAF levels were reduced to address the hypothesis that PAF is important for the development of insulitis. From the age of 35 days on, DP-BB rats were treated with human recombinant PAF...

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