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Article

Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats.

Diabetes - 1 Jun 1990

Markholst H, Klaff L J, Klöppel G, Lernmark A, Mordes J P, Palmer J

Abstract excerpt

Insulin autoantibodies (IAAs) occur in newly diagnosed human insulin-dependent diabetes mellitus (IDDM) patients, but their presence in BB rats is controversial, possibly due to assay differences or variability in the animals studied. To resolve this controversy, IAAs were measured in well-characterized inbred BB rats both in radioligand assays with 125I-labeled rat insulin I or II, respectively, and in an...

Topics

Aging
Animals
Autoantibodies
Diabetes Mellitus
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease
Insulin
Male
Pancreas
Radioligand Assay
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred BB

Rats, Inbred Strains

Reference Values

Regression Analysis

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Identifiers

PMID: 2189763
DOI: 10.2337/diab.39.6.720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2189763-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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