Absence or low number of telomere repeats at junctions of dicentric chromosomes

Abstract excerpt

Human ovarian surface epithelial (HOSE) cells transfected with the E6 and E7 oncogenes of the human papilloma virus (PV) do not express measurable telomerase activity. Relative to untransfected control cells, HOSE-PV cells have an extended in vitro lifespan characterized by a very high frequency of telomeric associations (TAs) of chromosomes. In order to study the role of telomere shortening in the formation of...

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• Share to Chromosomal and Genetic Variations
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• Share to Telomeres, Telomerase, and Senescence