Article

Structure and Variability of Human Chromosome Ends

1990-02-01

Abstract excerpt

Mammalian telomeres are thought to be composed of a tandem array of TTAGGG repeats. To further define the type and arrangement of sequences at the ends of human chromosomes, we developed a direct cloning strategy for telomere-associated DNA. The method involves a telomere enrichment procedure based on the relative lack of restriction endonuclease cutting sites near the ends of human chromosomes. Nineteen (TTAGGG)n...

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Literature Corpus work: bb518d99-05b1-5194-99a4-e86beab66496
DOI: 10.1128/mcb.10.2.518-527.1990

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