Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutator phenotype induced by aberrant replication.

Molecular and cellular biology - 1 Feb 1999

Liu V F, Bhaumik D, Wang T S

Abstract excerpt

We have identified thermosensitive mutants of five Schizosaccharomyces pombe replication proteins that have a mutator phenotype at their semipermissive temperatures. Allele-specific mutants of DNA polymerase delta (poldelta) and mutants of Polalpha, two Poldelta subunits, and ligase exhibited increased rates of deletion of sequences flanked by short direct repeats. Deletion of rad2(+), which encodes a nuclease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA, Fungal
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Mutation

Share to Phenotype

Share to Repetitive Sequences, Nucleic Acid

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 9891047
DOI: 10.1128/MCB.19.2.1126
PMCID: PMC116042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutator phenotype induced by aberrant replication.PMID 9891047Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.Semantic proximity Read ↗

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Semantic proximity Read ↗

Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.Semantic proximity Read ↗

Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.Semantic proximity Read ↗

DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.Semantic proximity Read ↗

DNA repeat rearrangements mediated by DnaK-dependent replication fork repair.Semantic proximity Read ↗

Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase delta subunit, Pol31.Semantic proximity Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.