Article
Mutator phenotype induced by aberrant replication.
Molecular and cellular biology - 1 Feb 1999
Liu V F, Bhaumik D, Wang T S
Abstract excerpt
We have identified thermosensitive mutants of five Schizosaccharomyces pombe replication proteins that have a mutator phenotype at their semipermissive temperatures. Allele-specific mutants of DNA polymerase delta (poldelta) and mutants of Polalpha, two Poldelta subunits, and ligase exhibited inc...
Topics
- Alleles
- Checkpoint Kinase 2
- DNA Ligases
- DNA Polymerase I
- DNA Polymerase III
- DNA Replication
- DNA, Fungal
- Gene Deletion
- Genes, Fungal
- Mutation
- Phenotype
- Protein Kinases
- Protein Serine-Threonine Kinases
- Repetitive Sequences, Nucleic Acid
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Temperature