Article
Expression of calbindin-D28k in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid beta-peptide.
Brain research. Molecular brain research - 22 Jan 1999
Wernyj R P, Mattson M P, Christakos S
Abstract excerpt
The calcium binding protein, calbindin-D28k is normally present in neurons. Recently we reported that brain injury and tumor necrosis factors (TNFs) induce calbindin-D28k in astrocytes. TNF-treated calbindin expressing astrocytes were resistant to acidosis and calcium ionophore toxicity, suggesti...
Topics
- Amyloid beta-Peptides
- Animals
- Apoptosis
- Astrocytes
- Astrocytoma
- Calbindin 1
- Calbindins
- Calcimycin
- Calcium
- Cell Division
- Gene Expression
- Ionophores
- Mitochondria
- Nerve Tissue Proteins
- Phenotype
- Plasmids
- Rats
- S100 Calcium Binding Protein G