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Article

Functional role of death-associated protein 3 (DAP3) in anoikis.

The Journal of biological chemistry - 22 Oct 2004

Miyazaki Tadaaki, Shen Min, Fujikura Daisuke, Tosa Noriko, Kim Hyung-Ryong, Kon Shigeyuki, Uede Toshimitsu, Reed John C

Abstract excerpt

Detachment of adherent epithelial cells from the extracellular matrix induces apoptosis, known as anoikis. Integrin stimulation protects cells from anoikis, but the responsible mechanisms are not well known. Here, we demonstrated that a pro-apoptotic GTP-binding protein, DAP3 (death-associated protein 3), is critical for induction of anoikis. Down-regulation of DAP3 expression by antisense oligonucleotides...

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Source

Identifiers

PMID: 15302871
DOI: 10.1074/jbc.M408101200

Genes

DAP3
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional role of death-associated protein 3 (DAP3) in anoikis.PMID 15302871Read ↗

The role of death-associated protein 3 in apoptosis, anoikis and human cancerSemantic proximity Read ↗

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Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and DifferentiationSemantic proximity Read ↗

Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.Semantic proximity Read ↗

Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death.Semantic proximity Read ↗

Human Intestinal Epithelial Cell Survival and AnoikisSemantic proximity Read ↗

Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro.Semantic proximity Read ↗

The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins.Semantic proximity Read ↗

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