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Article

A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF)

12 Jul 2002

Abstract excerpt

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. We have identified PRG3 (p53-responsive gene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa. PRG3 has significant homology to bacterial oxidoreductases and...

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PMID: 12135761
DOI: 10.1016/s0014-5793(02)03049-1

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