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DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death

1 Mar 1997

Abstract excerpt

A functional approach to gene cloning was applied to HeLa cells in an attempt to isolate cDNA fragments which convey resistance to gamma interferon (IFN-gamma)-induced programmed cell death. One of the rescued cDNAs, described in this work, was a fragment of a novel gene, named DAP-5. Analysis of a DAP-5 full-length cDNA clone revealed that it codes for a 97-kDa protein that is highly homologous to eukaryotic...

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PMID: 9032289
DOI: 10.1128/mcb.17.3.1615

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DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell DeathPMID 9032289Read ↗

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genesSemantic proximity Read ↗

Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.Semantic proximity Read ↗

DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity.Semantic proximity Read ↗

Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG.Semantic proximity Read ↗

Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1Semantic proximity Read ↗

DAP5 Promotes Cap-Independent Translation of Bcl-2 and CDK1 to Facilitate Cell Survival during MitosisSemantic proximity Read ↗

Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway.Semantic proximity Read ↗

The DEAD-box RNA helicase Dbp5 functions in translation termination.Semantic proximity Read ↗

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.Semantic proximity Read ↗

Interferon Regulatory Factor 5 (IRF5) Interacts with the Translation Initiation Complex and Promotes mRNA Translation During the Integrated Stress Response to Amino Acid DeprivationSemantic proximity Read ↗

The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stressSemantic proximity Read ↗

Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.Semantic proximity Read ↗

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