Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conserved Cysteine-Rich Domain of Paramyxovirus Simian Virus 5 V Protein Plays an Important Role in Blocking Apoptosis

28 Apr 2004

Abstract excerpt

The paramyxovirus family includes many well-known human and animal pathogens as well as emerging viruses such as Hendra virus and Nipah virus. The V protein of simian virus 5 (SV5), a prototype of the paramyxoviruses, contains a cysteine-rich C-terminal domain which is conserved among all paramyxovirus V proteins. The V protein can block both interferon (IFN) signaling by causing degradation of STAT1 and IFN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Virology and Viral Diseases
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15113888
DOI: 10.1128/jvi.78.10.5068-5078.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved Cysteine-Rich Domain of Paramyxovirus Simian Virus 5 V Protein Plays an Important Role in Blocking ApoptosisPMID 15113888Read ↗

Induction of Apoptosis by Paramyxovirus Simian Virus 5 Lacking a Small Hydrophobic GeneSemantic proximity Read ↗

The SH Integral Membrane Protein of the Paramyxovirus Simian Virus 5 Is Required To Block Apoptosis in MDBK CellsSemantic proximity Read ↗

Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-beta induction and interferon signaling.Semantic proximity Read ↗

Apoptosis induction and interferon signaling but not IFN-beta promoter induction by an SV5 P/V mutant are rescued by coinfection with wild-type SV5.Semantic proximity Read ↗

Naturally Occurring Substitutions in the P/V Gene Convert the Noncytopathic Paramyxovirus Simian Virus 5 into a Virus That Induces Alpha/Beta Interferon Synthesis and Cell DeathSemantic proximity Read ↗

MAVS-Mediated Apoptosis and Its Inhibition by Viral ProteinsSemantic proximity Read ↗

Paramyxovirus strategies for evading the interferon responseSemantic proximity Read ↗

The Paramyxovirus Simian Virus 5 V Protein Slows Progression of the Cell CycleSemantic proximity Read ↗

Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronavirusesSemantic proximity Read ↗

RIG-I-MAVS-NOXA axis coordinates antiviral defense and apoptosis during parahenipavirus infectionSemantic proximity Read ↗

Vesicular stomatitis viruses expressing wild-type or mutant M proteins activate apoptosis through distinct pathways.Semantic proximity Read ↗

Parvovirus Infection-Induced Cell Death and Cell Cycle ArrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.