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Article

Mitochondrial cell death suppressors carried by human and murine cytomegalovirus confer resistance to proteasome inhibitor-induced apoptosis.

Journal of virology - 1 Oct 2005

McCormick A Louise, Meiering Christopher D, Smith Geoffrey B, Mocarski Edward S

Abstract excerpt

Human cytomegalovirus carries a mitochondria-localized inhibitor of apoptosis (vMIA) that is conserved in primate cytomegaloviruses. We find that inactivating mutations within UL37x1, which encodes vMIA, do not substantially affect replication in TownevarATCC (Towne-BAC), a virus that carries a functional copy of the betaherpesvirus-conserved viral inhibitor of caspase 8 activation, the UL36 gene product. In...

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Identifiers

PMID: 16160147
DOI: 10.1128/JVI.79.19.12205-12217.2005
PMCID: PMC1211555

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Source receipt: pubmed, retrieved 7 Sept 2026.

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